题 目：Mechanotransduction through cell surface receptors（细胞表面受体介导的力学信号转导）

       报告人：朱承 教授

       时 间：2025 年7月21日上午10：00

       地 点：当代楼530会议室

       个人简介：

       朱承教授是美国佐治亚理工学院和埃默里大学的总校董教授，担任乐福工学讲席教授（J.Erskine Love Endowed Chair）。他是师承Richard Skalak和Shu Chien（钱煦）的第一代细胞分子生物工程师之一，先后在哥伦比亚大学和加州大学圣地亚哥分校（UCSD）度过博士及博士后阶段，致力于细胞运动和细胞粘附的数学建模研究。 1990年，他在佐治亚理工学院开设了独立实验室。多年来，朱承教授的研究影响了生物科学的多个领域，包括Fc受体，白细胞生物学，整合素生物学，T细胞免疫学，止血和血栓形成，癌症和机械生物学，在Nature, Cell等期刊发表了200多篇论文，他率先分析了锚定在两个相应表面上的分子之间的连接界面处的相互作用。朱承教授是国际公认的分子相互作用机械调控研究领导者。由于他的杰出工作，机械力被引入成为生物分子相互作用分析的新维度。曾获美国生物医学工程学会Harold Lamport奖、美国机械工程师学会生物工程部的冯元桢奖、美国国家科学基金会的总统教授学者奖、国际临床血液流变学会的血液流变学与微循环奖等多项荣誉。

       Professor. Cheng Zhu is Regents’ Professor of the Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University and holds the J. Erskine Love Jr. Endowed Chair in Engineering. His research interest is in the molecular biophysics of the immune and vascular systems, with focuses in the mechanobiology of lymphocytes and platelets. He pioneered the analysis of in situ interactions at the junctional interface between molecules anchored to two apposing surfaces, i.e., two-dimensional interactions. His lab conceptualized and/or demonstrated several types of mechanical regulation of protein unbinding and unfolding (catch bonds, force-history, cyclic mechanical reinforcement, and dynamic catch) in a variety of receptor–ligand systems. Dr. Zhu founded the joint doctoral program with Peking University in 2007 and has been director of that program since then. Dr. Zhu received the Harold Lamport Award from the Biomedical Engineering Society in 1991, Yuan-Cheng Fung Award from American Mechanical Engineer Society in 1992, Presidential Faculty Fellows Award from National Science Foundation in 1993, and Award in Hemarheology and Microcirculation from International Clinical Society of Hemarheology in 2005. Dr. Zhu is a fellow of the American Institute for Medical and Biological Engineering and a fellow of the Biomedical Engineering Society.